Assay Detail
Binding
CHEMBL5540960
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Inhibition of recombinant human HDAC3 using Boc-Lys(Ac)-AMC as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by fluorescence based assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and Synthesis of Dual-Targeting Inhibitors of sEH and HDAC6 for the Treatment of Neuropathic Pain and Lipopolysaccharide-Induced Mortality.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.45 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5570460 | — | — | 1 | 8.40 |
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 8.05 |
| CHEMBL5567303 | — | — | 1 | 7.31 |
| CHEMBL5564312 | — | — | 1 | 7.29 |
| CHEMBL5592524 | — | — | 1 | 6.92 |
| CHEMBL356769 | TUBACIN | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5570460 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL408513 | BELINOSTAT | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5567303 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL5564312 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL5592524 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL356769 | TUBACIN | IC50 | = | 180.0 | nM | 6.75 |