Assay Detail
Functional
CHEMBL5541147
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Cytotoxicity against human NCI-H1975 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1975 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Multitargeting HDAC Inhibitors Containing a RAS/RAF Protein Interfering Unit.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.73 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5563252 | — | — | 1 | 7.30 |
| CHEMBL5563126 | — | — | 1 | 7.10 |
| CHEMBL1241855 | RIGOSERTIB | 3.0 | 1 | 6.64 |
| CHEMBL5573899 | — | — | 1 | 6.17 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.68 |
| CHEMBL5583720 | — | — | 1 | 5.66 |
| CHEMBL5574194 | — | — | 1 | 5.59 |
| CHEMBL5569054 | — | — | 1 | 5.40 |
| CHEMBL5562713 | — | — | 1 | 5.32 |
| CHEMBL5595107 | — | — | 1 | 5.29 |
| CHEMBL5579672 | — | — | 1 | 5.29 |
| CHEMBL5564383 | — | — | 1 | 5.07 |
| CHEMBL5574395 | — | — | 1 | 5.02 |
| CHEMBL5570354 | — | — | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5563252 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5563126 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1241855 | RIGOSERTIB | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5573899 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL5583720 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL5574194 | — | IC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL5569054 | — | IC50 | = | 3950.0 | nM | 5.40 |
| CHEMBL5562713 | — | IC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL5595107 | — | IC50 | = | 5110.0 | nM | 5.29 |
| CHEMBL5579672 | — | IC50 | = | 5080.0 | nM | 5.29 |
| CHEMBL5564383 | — | IC50 | = | 8450.0 | nM | 5.07 |
| CHEMBL5574395 | — | IC50 | = | 9480.0 | nM | 5.02 |
| CHEMBL5570354 | — | IC50 | = | 18760.0 | nM | 4.73 |