Assay Detail
Functional
CHEMBL5541328
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of ferroptosis in human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel Covalent Probe Selectively Targeting Glutathione Peroxidase 4 In Vivo: Potential Applications in Pancreatic Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.43 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1499544 | — | — | 1 | 8.43 |
| CHEMBL5569478 | — | — | 1 | - |
| CHEMBL1951048 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1499544 | — | IC50 | = | 3.71 | nM | 8.43 |
| CHEMBL5569478 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL1951048 | — | IC50 | > | 10.0 | nM | - |