Assay Detail
ADMET
CHEMBL5541704
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP1A2 in human liver microsomes incubated for 15 mins by LC-MS/MS analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of Piperazinyl-Difluoro-indene Derivatives Containing Pyridyl Groups as Potent FGFR Inhibitors against FGFR Mutant Tumor: Design, Synthesis, and Biological Evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.66 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26260 | BETA-NAPHTHOFLAVONE | — | 1 | 6.89 |
| CHEMBL5570406 | — | — | 1 | 4.42 |
| CHEMBL5571836 | — | — | 1 | - |
| CHEMBL5572540 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26260 | BETA-NAPHTHOFLAVONE | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5570406 | — | IC50 | = | 38400.0 | nM | 4.42 |
| CHEMBL5571836 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5572540 | — | IC50 | > | 50000.0 | nM | - |