Assay Detail
Functional
CHEMBL5543207
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Anti-inflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production incubated for 24 hrs by Griess reagent based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of anti-inflammatory natural flavonoids: Diverse scaffolds and promising leads for drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.96 | 5.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL210635 | GENKWANIN | — | 1 | 5.25 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 5.07 |
| CHEMBL5574700 | — | — | 1 | 4.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL210635 | GENKWANIN | IC50 | = | 5640.0 | nM | 5.25 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL5574700 | — | IC50 | = | 27700.0 | nM | 4.56 |