Assay Detail
Functional
CHEMBL5543230
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Anti-inflammatory activity against TNFalpha-induced HEK293 cells assessed as inhibition of NF-kappaB activity pre-indubated for 1 hr followed by TNFalpha treatment measured for 5 hrs by luciferase based assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of anti-inflammatory natural flavonoids: Diverse scaffolds and promising leads for drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.19 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4298697 | — | — | 1 | 5.82 |
| CHEMBL16171 | WOGONIN | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4298697 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL16171 | WOGONIN | IC50 | = | 28100.0 | nM | 4.55 |