Assay Detail
Functional
CHEMBL5543252
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Anti-inflammatory activity in mouse J774.A1 macrophage cells assessed as reduction in LPS-induced TNF-alpha production
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | J774.A1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of anti-inflammatory natural flavonoids: Diverse scaffolds and promising leads for drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.66 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL186478 | — | — | 1 | 6.66 |
| CHEMBL52676 | MOSLOFLAVONE | — | 1 | 6.66 |
| CHEMBL296800 | — | — | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL186478 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL52676 | MOSLOFLAVONE | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL296800 | — | IC50 | = | 220.0 | nM | 6.66 |