Compound Detail
CHEMBL52676
MOSLOFLAVONE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL52676 |
| Name | MOSLOFLAVONE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SIVAITYPYQQYAP-UHFFFAOYSA-N |
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
16
Publications
0
Known Names
Molecular Properties
298.3
MW (Da)
3.18
ALogP
5
HBA
1
HBD
68.9
PSA (Ų)
0.80
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 5.34
IC50 2 meas. best 6.66
Target Activity Profile
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| J774.A1 | IC50 | = | 220.0 | nM | 6.66 | Anti-inflammatory activity in mouse J774.A1 macrophage cells assessed as reducti... | 37683361 |
| KB 3-1 | EC50 | = | 4600.0 | nM | 5.34 | Concentration that causes 50% of maximum vinblastine accumulation in KB/MDR cell... | 15481991 |
| J774.A1 | IC50 | = | 6400.0 | nM | 5.19 | Antiinflammatory activity in LPS-induced mouse J774.A1 macrophage cells assessed... | 37683361 |
| HT-22 | EC50 | = | 23400.0 | nM | 4.63 | Neuroprotective activity against glutamate-induced cell death in mouse HT-22 cel... | 32991171 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15481991 | 10.1021/jm049949c | KB 3-1 | 3 |
| 12729671 | 10.1016/s0960-894x(03)00197-5 | H9 | 2 |
| 37683361 | 10.1016/j.ejmech.2023.115791 | J774.A1 | 2 |
| 16046127 | 10.1016/j.bmcl.2005.05.045 | Bacillus subtilis | 1 |
| 16046127 | 10.1016/j.bmcl.2005.05.045 | Bacillus sp. | 1 |
| 16046127 | 10.1016/j.bmcl.2005.05.045 | Staphylococcus aureus | 1 |
| 16046127 | 10.1016/j.bmcl.2005.05.045 | Klebsiella aerogenes | 1 |
| 16046127 | 10.1016/j.bmcl.2005.05.045 | NON-PROTEIN TARGET | 1 |
| 15481991 | 10.1021/jm049949c | KB | 1 |
| 15481991 | 10.1021/jm049949c | No relevant target | 1 |
| 20704331 | 10.1021/np100014j | MCF7 | 1 |
| 20704331 | 10.1021/np100014j | NCI-H460 | 1 |
| 20704331 | 10.1021/np100014j | SF-268 | 1 |
| - | 10.1007/s00044-011-9570-z | Avian myoblastosis virus polyprotein II | 1 |
| 12517100 | 10.1021/jf025627a | Spodoptera litura | 1 |
| 32991171 | 10.1021/acs.jnatprod.0c00756 | HT-22 | 1 |
Data from ChEMBL 36 via Core Engine