Assay Detail
Functional
CHEMBL833849
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration that causes 50% of maximum vinblastine accumulation in KB/MDR cells in 1 h
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB 3-1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Increased anti-P-glycoprotein activity of baicalein by alkylation on the A ring.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 36 | 5.43 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189669 | — | — | 1 | 6.05 |
| CHEMBL189501 | — | — | 1 | 6.00 |
| CHEMBL427335 | — | — | 1 | 5.96 |
| CHEMBL426074 | — | — | 1 | 5.96 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 5.92 |
| CHEMBL188612 | — | — | 1 | 5.92 |
| CHEMBL187406 | — | — | 1 | 5.89 |
| CHEMBL188627 | — | — | 1 | 5.85 |
| CHEMBL433947 | — | — | 1 | 5.82 |
| CHEMBL187929 | — | — | 1 | 5.82 |
| CHEMBL425355 | — | — | 1 | 5.82 |
| CHEMBL361663 | — | — | 1 | 5.80 |
| CHEMBL185944 | — | — | 1 | 5.77 |
| CHEMBL434537 | — | — | 1 | 5.75 |
| CHEMBL362732 | — | — | 1 | 5.75 |
| CHEMBL186132 | — | — | 1 | 5.75 |
| CHEMBL186490 | — | — | 1 | 5.70 |
| CHEMBL189339 | — | — | 1 | 5.64 |
| CHEMBL188583 | — | — | 1 | 5.62 |
| CHEMBL186733 | — | — | 1 | 5.43 |
| CHEMBL186478 | — | — | 1 | 5.36 |
| CHEMBL52676 | MOSLOFLAVONE | — | 1 | 5.34 |
| CHEMBL182992 | BAICALEIN TRIMETHYL ETHER | — | 1 | 5.26 |
| CHEMBL364596 | — | — | 1 | 5.19 |
| CHEMBL426444 | — | — | 1 | 5.17 |
| CHEMBL189502 | — | — | 1 | 5.13 |
| CHEMBL188688 | — | — | 1 | 5.01 |
| CHEMBL363317 | — | — | 1 | 4.96 |
| CHEMBL187982 | — | — | 1 | 4.94 |
| CHEMBL365255 | — | — | 1 | 4.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189669 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL189501 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL426074 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL427335 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL160 | CYCLOSPORINE | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL188612 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL187406 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL188627 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL425355 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL187929 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL433947 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL361663 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL185944 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL186132 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL362732 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL434537 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL186490 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL189339 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL188583 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL186733 | — | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL186478 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL52676 | MOSLOFLAVONE | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL182992 | BAICALEIN TRIMETHYL ETHER | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL364596 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL426444 | — | EC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL189502 | — | EC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL188688 | — | EC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL363317 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL187982 | — | EC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL365255 | — | EC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL188192 | — | EC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL6966 | VERAPAMIL | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL190585 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL187405 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL8260 | BAICALEIN | EC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL187876 | — | EC50 | = | 70000.0 | nM | 4.16 |