Assay Detail
Functional
CHEMBL5543296
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Anti-inflammatory activity in mouse BV-2 cells assessed as inhibition of LPS-induced NO production preincubated with compound for 1 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BV-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of anti-inflammatory natural flavonoids: Diverse scaffolds and promising leads for drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.05 | 5.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL163316 | 3-O-METHYLQUERCETIN | — | 1 | 5.42 |
| CHEMBL164861 | — | — | 1 | 5.38 |
| CHEMBL309263 | — | — | 1 | 4.96 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 4.90 |
| CHEMBL74898 | AYANIN | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL163316 | 3-O-METHYLQUERCETIN | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL164861 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL309263 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL50 | QUERCETIN | IC50 | = | 12580.0 | nM | 4.90 |
| CHEMBL74898 | AYANIN | IC50 | = | 25100.0 | nM | 4.60 |