Assay Detail
Functional
CHEMBL5543324
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Antiinflammatory activity against mouse BV-2 cells assessed as reduction in LPS induced NO production measured for 24 hrs by Griess reagent based analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BV-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of anti-inflammatory natural flavonoids: Diverse scaffolds and promising leads for drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.62 | 4.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL256147 | TILARGININE | 3.0 | 1 | 4.83 |
| CHEMBL311498 | CIANIDANOL | 4.0 | 1 | 4.58 |
| CHEMBL129482 | (+)-EPICATECHIN | 2.0 | 1 | 4.54 |
| CHEMBL125743 | GALLOCATECHIN | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL256147 | TILARGININE | IC50 | = | 14770.0 | nM | 4.83 |
| CHEMBL311498 | CIANIDANOL | IC50 | = | 26110.0 | nM | 4.58 |
| CHEMBL129482 | (+)-EPICATECHIN | IC50 | = | 29080.0 | nM | 4.54 |
| CHEMBL125743 | GALLOCATECHIN | IC50 | = | 30260.0 | nM | 4.52 |