Assay Detail
Binding
CHEMBL5543475
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Binding affinity to caspase-1 (unknown origin) assessed as inhibition constant
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Interleukin-1β converting enzyme (ICE): A comprehensive review on discovery and development of caspase-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.22 | 9.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL115090 | — | — | 1 | 9.43 |
| CHEMBL366456 | — | — | 1 | 9.12 |
| CHEMBL366534 | — | — | 1 | 9.07 |
| CHEMBL368313 | — | — | 1 | 8.94 |
| CHEMBL176584 | — | — | 1 | 8.75 |
| CHEMBL5570795 | — | — | 1 | 8.40 |
| CHEMBL165535 | — | — | 1 | 7.70 |
| CHEMBL3898379 | — | — | 1 | 7.32 |
| CHEMBL1412861 | — | — | 1 | 7.30 |
| CHEMBL283789 | — | — | 1 | 7.05 |
| CHEMBL5573561 | — | — | 1 | 6.07 |
| CHEMBL5563710 | — | — | 1 | 5.80 |
| CHEMBL5564598 | — | — | 1 | 5.72 |
| CHEMBL5573649 | — | — | 1 | 5.16 |
| CHEMBL422379 | — | — | 1 | 4.96 |
| CHEMBL167557 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL115090 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL366456 | — | Ki | = | 0.76 | nM | 9.12 |
| CHEMBL366534 | — | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL368313 | — | Ki | = | 1.15 | nM | 8.94 |
| CHEMBL176584 | — | Ki | = | 1.79 | nM | 8.75 |
| CHEMBL5570795 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL165535 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL3898379 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL1412861 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL283789 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL5573561 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL5563710 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL5564598 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL5573649 | — | Ki | = | 6900.0 | nM | 5.16 |
| CHEMBL422379 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL167557 | — | Ki | = | 16000.0 | nM | 4.80 |