Assay Detail
Binding
CHEMBL5543483
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Interleukin-1beta-converting enzyme (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Interleukin-1β converting enzyme (ICE): A comprehensive review on discovery and development of caspase-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.34 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5572589 | — | — | 1 | 7.72 |
| CHEMBL301982 | CELASTROL | — | 1 | 7.40 |
| CHEMBL54804 | PRISTIMERIN | — | 1 | 7.25 |
| CHEMBL432519 | TINGENONE | — | 1 | 7.24 |
| CHEMBL292578 | PRISTIMEROL DIACETATE | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5572589 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL301982 | CELASTROL | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL54804 | PRISTIMERIN | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL432519 | TINGENONE | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL292578 | PRISTIMEROL DIACETATE | IC50 | = | 79.0 | nM | 7.10 |