Assay Detail
Binding
CHEMBL5543640
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of AXL (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein kinase receptor UFO (CHEMBL4895) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationship study of 1,6-naphthyridinone derivatives as selective type II AXL inhibitors with potent antitumor efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.62 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3984441 | NINGETINIB | 2.0 | 1 | 9.00 |
| CHEMBL3545307 | MERESTINIB | 2.0 | 1 | 8.70 |
| CHEMBL4776274 | — | — | 1 | 8.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3984441 | NINGETINIB | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3545307 | MERESTINIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4776274 | — | IC50 | = | 7.0 | nM | 8.15 |