Assay Detail
Binding
CHEMBL5543642
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Inhibition of recombinant MET (unknown origin)
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationship study of 1,6-naphthyridinone derivatives as selective type II AXL inhibitors with potent antitumor efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.06 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL460702 | BMS-777607 | 2.0 | 1 | 8.12 |
| CHEMBL5574768 | — | — | 1 | 7.55 |
| CHEMBL5570772 | — | — | 1 | 7.48 |
| CHEMBL5570992 | — | — | 1 | 7.34 |
| CHEMBL5594055 | — | — | 1 | 7.33 |
| CHEMBL5563765 | — | — | 1 | 7.33 |
| CHEMBL5573302 | — | — | 1 | 7.29 |
| CHEMBL5569554 | — | — | 1 | 7.26 |
| CHEMBL5570274 | — | — | 1 | 7.24 |
| CHEMBL5575269 | — | — | 1 | 7.22 |
| CHEMBL5572537 | — | — | 1 | 7.17 |
| CHEMBL5572673 | — | — | 1 | 7.16 |
| CHEMBL4781305 | — | — | 1 | 7.12 |
| CHEMBL5569183 | — | — | 1 | 7.09 |
| CHEMBL5574080 | — | — | 1 | 7.01 |
| CHEMBL5595200 | — | — | 1 | 7.00 |
| CHEMBL5574134 | — | — | 1 | 6.96 |
| CHEMBL5575968 | — | — | 1 | 6.93 |
| CHEMBL5574121 | — | — | 1 | 6.70 |
| CHEMBL5572307 | — | — | 1 | 6.68 |
| CHEMBL5569411 | — | — | 1 | 6.53 |
| CHEMBL5595612 | — | — | 1 | 6.46 |
| CHEMBL5565630 | — | — | 1 | 6.42 |
| CHEMBL5571226 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL460702 | BMS-777607 | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL5574768 | — | IC50 | = | 28.3 | nM | 7.55 |
| CHEMBL5570772 | — | IC50 | = | 33.39 | nM | 7.48 |
| CHEMBL5570992 | — | IC50 | = | 45.7 | nM | 7.34 |
| CHEMBL5594055 | — | IC50 | = | 46.64 | nM | 7.33 |
| CHEMBL5563765 | — | IC50 | = | 46.51 | nM | 7.33 |
| CHEMBL5573302 | — | IC50 | = | 51.3 | nM | 7.29 |
| CHEMBL5569554 | — | IC50 | = | 55.3 | nM | 7.26 |
| CHEMBL5570274 | — | IC50 | = | 57.11 | nM | 7.24 |
| CHEMBL5575269 | — | IC50 | = | 59.94 | nM | 7.22 |
| CHEMBL5572537 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL5572673 | — | IC50 | = | 69.31 | nM | 7.16 |
| CHEMBL4781305 | — | IC50 | = | 76.6 | nM | 7.12 |
| CHEMBL5569183 | — | IC50 | = | 80.3 | nM | 7.09 |
| CHEMBL5574080 | — | IC50 | = | 96.7 | nM | 7.01 |
| CHEMBL5595200 | — | IC50 | = | 101.1 | nM | 7.00 |
| CHEMBL5574134 | — | IC50 | = | 108.9 | nM | 6.96 |
| CHEMBL5575968 | — | IC50 | = | 116.3 | nM | 6.93 |
| CHEMBL5574121 | — | IC50 | = | 197.8 | nM | 6.70 |
| CHEMBL5572307 | — | IC50 | = | 210.6 | nM | 6.68 |
| CHEMBL5569411 | — | IC50 | = | 296.1 | nM | 6.53 |
| CHEMBL5595612 | — | IC50 | = | 347.0 | nM | 6.46 |
| CHEMBL5565630 | — | IC50 | = | 377.0 | nM | 6.42 |
| CHEMBL5571226 | — | IC50 | = | 686.0 | nM | 6.16 |