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Assay Detail

CHEMBL5543732

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of C57BL/6J mouse brain sEH using 14,15-EET as substrate preincubated for 15 mins followed by substrate addition by LC-MS analysis
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Bifunctional epoxide hydrolase 2 (CHEMBL4140)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Discovery of a novel lead characterized by a stilbene-extended scaffold against sepsis as soluble epoxide hydrolase inhibitors.
Feng ZQ, Ding J, Zhu MZ, Xie WS, Liu RC, Liu SS, Liu SM, Yu MJ, Zhu XH, Liang JH.
Eur J Med Chem (2024) 266 : 116113 -116113
PubMed 38215588 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 46 7.89 8.91

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5595233 1 8.91
CHEMBL5572456 1 8.91
CHEMBL5563278 1 8.90
CHEMBL5565702 1 8.85
CHEMBL5573585 1 8.85
CHEMBL5569380 1 8.79
CHEMBL5583592 1 8.72
CHEMBL5567544 1 8.69
CHEMBL5572912 1 8.69
CHEMBL5572021 1 8.60
CHEMBL5571810 1 8.57
CHEMBL5566013 1 8.56
CHEMBL5583829 1 8.49
CHEMBL5570116 1 8.49
CHEMBL5569740 1 8.48
CHEMBL5575802 1 8.46
CHEMBL5572264 1 8.40
CHEMBL5573304 1 8.34
CHEMBL5579736 1 8.32
CHEMBL5570373 1 8.24
CHEMBL5569391 1 8.17
CHEMBL5562723 1 8.10
CHEMBL5569926 1 8.07
CHEMBL5569366 1 7.84
CHEMBL4752759 1 7.72
CHEMBL5563324 1 7.63
CHEMBL1258904 1 7.36
CHEMBL5591563 1 7.35
CHEMBL5574809 1 7.17
CHEMBL5571437 1 7.04

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5595233 IC50 = 1.24 nM 8.91
CHEMBL5572456 IC50 = 1.22 nM 8.91
CHEMBL5563278 IC50 = 1.26 nM 8.90
CHEMBL5565702 IC50 = 1.4 nM 8.85
CHEMBL5573585 IC50 = 1.42 nM 8.85
CHEMBL5569380 IC50 = 1.63 nM 8.79
CHEMBL5583592 IC50 = 1.92 nM 8.72
CHEMBL5567544 IC50 = 2.03 nM 8.69
CHEMBL5572912 IC50 = 2.03 nM 8.69
CHEMBL5572021 IC50 = 2.53 nM 8.60
CHEMBL5571810 IC50 = 2.68 nM 8.57
CHEMBL5566013 IC50 = 2.74 nM 8.56
CHEMBL5570116 IC50 = 3.23 nM 8.49
CHEMBL5583829 IC50 = 3.21 nM 8.49
CHEMBL5569740 IC50 = 3.31 nM 8.48
CHEMBL5575802 IC50 = 3.45 nM 8.46
CHEMBL5572264 IC50 = 4.02 nM 8.40
CHEMBL5573304 IC50 = 4.59 nM 8.34
CHEMBL5579736 IC50 = 4.76 nM 8.32
CHEMBL5570373 IC50 = 5.78 nM 8.24
CHEMBL5569391 IC50 = 6.72 nM 8.17
CHEMBL5562723 IC50 = 8.02 nM 8.10
CHEMBL5569926 IC50 = 8.42 nM 8.07
CHEMBL5569366 IC50 = 14.28 nM 7.84
CHEMBL4752759 IC50 = 19.11 nM 7.72
CHEMBL5563324 IC50 = 23.33 nM 7.63
CHEMBL1258904 IC50 = 43.77 nM 7.36
CHEMBL5591563 IC50 = 44.51 nM 7.35
CHEMBL5574809 IC50 = 67.39 nM 7.17
CHEMBL5571437 IC50 = 91.28 nM 7.04
CHEMBL5583584 IC50 = 200.0 nM 6.70
CHEMBL5567256 IC50 = 644.0 nM 6.19
CHEMBL5565488 IC50 = 908.36 nM 6.04
CHEMBL5573178 IC50 = 2600.0 nM 5.58
CHEMBL5575437 IC50 = 2740.0 nM 5.56
CHEMBL5566205 IC50 = 5200.0 nM 5.28
CHEMBL5589971 IC50 - -
CHEMBL5593024 IC50 - -
CHEMBL5572388 IC50 - -
CHEMBL5562597 IC50 - -
CHEMBL5579752 IC50 - -
CHEMBL5575665 IC50 - -
CHEMBL5569000 IC50 - -
CHEMBL5563996 IC50 - -
CHEMBL5571376 IC50 - -
CHEMBL5565382 IC50 - -