Assay Detail
Binding
CHEMBL5543915
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Inhibition of human COX-2
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A further pocket or conformational plasticity by mapping COX-1 catalytic site through modified-mofezolac structure-inhibitory activity relationships and their antiplatelet behavior.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.64 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL365033 | — | — | 1 | 5.60 |
| CHEMBL275809 | FR-122047 | — | 1 | 4.19 |
| CHEMBL26915 | SC-560 | — | 1 | 4.13 |
| CHEMBL363228 | — | — | 1 | - |
| CHEMBL361504 | — | — | 1 | - |
| CHEMBL5574567 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL365033 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL275809 | FR-122047 | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL26915 | SC-560 | IC50 | = | 74900.0 | nM | 4.13 |
| CHEMBL363228 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL361504 | — | IC50 | > | 1490.0 | nM | - |
| CHEMBL5574567 | — | IC50 | > | 100000.0 | nM | - |