Assay Detail
Binding
CHEMBL5545175
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Inhibition of TNIK (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
TRAF2 and NCK-interacting protein kinase (CHEMBL4527) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Fragment growth-based discovery of novel TNIK inhibitors for the treatment of colorectal cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.63 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL214253 | — | — | 1 | 9.15 |
| CHEMBL2312148 | — | — | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL214253 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL2312148 | — | IC50 | = | 8.0 | nM | 8.10 |