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Assay Detail

CHEMBL5545819

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of C57BL/6J mouse Alpha-glucosidase incubated for 10 mins by Lineweaver-Burk plot analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Amphiphilic α-Peptoid-deoxynojirimycin Conjugate-based Multivalent Glycosidase Inhibitor for Hypoglycemic Effect and Fluorescence Imaging.
Wang GY, Yan DX, Rong RX, Shi BY, Lin GJ, Yin F, Wei WT, Li XL, Wang KR.
J Med Chem (2024) 67 : 5945 -5956
PubMed 38504504 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 4 5.91 7.41

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL307429 DUVOGLUSTAT 2.0 1 7.41
CHEMBL1561 MIGLITOL 4.0 1 5.84
CHEMBL5573135 1 5.57
CHEMBL5570547 1 4.81

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL307429 DUVOGLUSTAT Ki = 39.0 nM 7.41
CHEMBL1561 MIGLITOL Ki = 1460.0 nM 5.84
CHEMBL5573135 Ki = 2700.0 nM 5.57
CHEMBL5570547 Ki = 15400.0 nM 4.81