Assay Detail
Functional
CHEMBL5546060
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human BT-474 cells by CellTiter-Glo assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BT-474 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel 5,6-Dihydro-4<i>H</i>-pyrido[2,3,4-<i>de</i>]quinazoline Irreversible Inhibitors Targeting Both Wild-Type and A775_G776insYVMA Mutated HER2 Kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.79 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL180022 | NERATINIB | 4.0 | 1 | 8.00 |
| CHEMBL5563672 | — | — | 1 | 7.82 |
| CHEMBL5572660 | — | — | 1 | 7.76 |
| CHEMBL5572514 | — | — | 1 | 7.75 |
| CHEMBL5570443 | — | — | 1 | 7.73 |
| CHEMBL5569244 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL180022 | NERATINIB | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5563672 | — | IC50 | = | 15.17 | nM | 7.82 |
| CHEMBL5572660 | — | IC50 | = | 17.38 | nM | 7.76 |
| CHEMBL5572514 | — | IC50 | = | 17.93 | nM | 7.75 |
| CHEMBL5570443 | — | IC50 | = | 18.55 | nM | 7.73 |
| CHEMBL5569244 | — | IC50 | = | 20.18 | nM | 7.70 |