Assay Detail
Binding
CHEMBL5546247
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of FL-H3K4me3 peptide from human N-terminal His10 tagged SPIN1 (G21 to S262 residues) expressed in Escherichia coli BL21 (DE3) incubated for 30 mins by fluorescence polarization assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Potent, Selective, and Cell-Active SPIN1 Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.08 | 6.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5570983 | — | — | 1 | 6.73 |
| CHEMBL5572612 | — | — | 1 | 6.71 |
| CHEMBL5575071 | — | — | 1 | 6.70 |
| CHEMBL5594627 | — | — | 1 | 6.70 |
| CHEMBL5575917 | — | — | 1 | 6.69 |
| CHEMBL5564247 | — | — | 1 | 6.67 |
| CHEMBL5583678 | — | — | 1 | 6.67 |
| CHEMBL5572650 | — | — | 1 | 6.51 |
| CHEMBL5590823 | — | — | 1 | 6.49 |
| CHEMBL5568957 | — | — | 1 | 6.46 |
| CHEMBL5565204 | — | — | 1 | 6.08 |
| CHEMBL5573051 | — | — | 1 | 5.88 |
| CHEMBL5572233 | — | — | 1 | 5.76 |
| CHEMBL5573430 | — | — | 1 | 5.69 |
| CHEMBL5575971 | — | — | 1 | 5.40 |
| CHEMBL1231795 | — | — | 1 | 5.13 |
| CHEMBL5593870 | — | — | 1 | 5.10 |
| CHEMBL5584133 | — | — | 1 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5570983 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL5572612 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL5575071 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5594627 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL5575917 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL5564247 | — | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL5583678 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL5572650 | — | IC50 | = | 312.0 | nM | 6.51 |
| CHEMBL5590823 | — | IC50 | = | 326.0 | nM | 6.49 |
| CHEMBL5568957 | — | IC50 | = | 348.0 | nM | 6.46 |
| CHEMBL5565204 | — | IC50 | = | 838.0 | nM | 6.08 |
| CHEMBL5573051 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL5572233 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL5573430 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL5575971 | — | IC50 | = | 3990.0 | nM | 5.40 |
| CHEMBL1231795 | — | IC50 | = | 7360.0 | nM | 5.13 |
| CHEMBL5593870 | — | IC50 | = | 7970.0 | nM | 5.10 |
| CHEMBL5584133 | — | IC50 | = | 84300.0 | nM | 4.07 |