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Assay Detail

CHEMBL5546320

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Toxicity
Antagonist activity at HTR2B (unknown origin) by calcium flux assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Toxicity
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 2B (CHEMBL1833)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Lead Compound Development of SRC-3 Inhibitors with Improved Pharmacokinetic Properties and Anticancer Efficacy.
Lu D, Chen J, Qin L, Bijou I, Yi P, Li F, Song X, MacKenzie KR, Yu X, Yang B, Roy Chowdhury S, Korp JD, O'Malley BW, Lonard DM, Wang J.
J Med Chem (2024) 67 : 5333 -5350
PubMed 38551814 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.39 5.39

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5590309 1 5.39

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5590309 IC50 = 4100.0 nM 5.39