Assay Detail
Binding
CHEMBL5547422
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK293 cell membrane incubated for 90 mins by microbeta liquid scintillation counting method
28
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Structure-Activity Relationships of 2,5-Dimethoxy-4-Substituted Phenethylamines and the Discovery of CYB210010: A Potent, Orally Bioavailable and Long-Acting Serotonin 5-HT<sub>2</sub> Receptor Agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 7.91 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5569144 | — | — | 2 | 8.35 |
| CHEMBL5573972 | — | — | 2 | 8.26 |
| CHEMBL5589604 | — | — | 2 | 8.21 |
| CHEMBL5572387 | — | — | 2 | 8.19 |
| CHEMBL5563542 | — | — | 2 | 8.17 |
| CHEMBL5574455 | — | — | 2 | 8.08 |
| CHEMBL5584114 | — | — | 2 | 8.00 |
| CHEMBL5566821 | — | — | 1 | 7.85 |
| CHEMBL5572320 | — | — | 2 | 7.70 |
| CHEMBL5565116 | — | — | 2 | 7.63 |
| CHEMBL5573377 | — | — | 2 | 7.59 |
| CHEMBL5594012 | — | — | 2 | 7.56 |
| CHEMBL5566251 | — | — | 2 | 7.18 |
| CHEMBL5570285 | — | — | 1 | - |
| CHEMBL5570258 | — | — | 1 | - |
| CHEMBL5570359 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5569144 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL5569144 | — | Ki | = | 4.467 | nM | 8.35 |
| CHEMBL5573972 | — | Ki | = | 5.495 | nM | 8.26 |
| CHEMBL5573972 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL5589604 | — | Ki | = | 6.166 | nM | 8.21 |
| CHEMBL5589604 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL5572387 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL5572387 | — | Ki | = | 6.457 | nM | 8.19 |
| CHEMBL5563542 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL5563542 | — | Ki | = | 6.761 | nM | 8.17 |
| CHEMBL5574455 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL5574455 | — | Ki | = | 8.511 | nM | 8.07 |
| CHEMBL5584114 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL5584114 | — | Ki | = | 10.23 | nM | 7.99 |
| CHEMBL5566821 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL5572320 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL5572320 | — | Ki | = | 20.42 | nM | 7.69 |
| CHEMBL5565116 | — | Ki | = | 23.44 | nM | 7.63 |
| CHEMBL5565116 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL5573377 | — | Ki | = | 25.7 | nM | 7.59 |
| CHEMBL5573377 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL5594012 | — | Ki | = | 27.54 | nM | 7.56 |
| CHEMBL5594012 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL5566251 | — | Ki | = | 66.07 | nM | 7.18 |
| CHEMBL5566251 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL5570359 | — | Ki | - | — | - | |
| CHEMBL5570258 | — | Ki | - | — | - | |
| CHEMBL5570285 | — | Ki | - | — | - |