Assay Detail
Binding
CHEMBL5547464
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-rauwolscine from human recombinant adrenergic alpha-2A receptor expressed in CHO-K1 cells incubated for 60 mins by spectrophotometric analysis relative to control
6
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Structure-Activity Relationships of 2,5-Dimethoxy-4-Substituted Phenethylamines and the Discovery of CYB210010: A Potent, Orally Bioavailable and Long-Acting Serotonin 5-HT<sub>2</sub> Receptor Agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.76 | 8.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15245 | YOHIMBINE | 3.0 | 2 | 8.58 |
| CHEMBL134 | CLONIDINE | 4.0 | 2 | 7.59 |
| CHEMBL5566821 | — | — | 2 | 7.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15245 | YOHIMBINE | Ki | = | 2.63 | nM | 8.58 |
| CHEMBL15245 | YOHIMBINE | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL134 | CLONIDINE | Ki | = | 25.7 | nM | 7.59 |
| CHEMBL134 | CLONIDINE | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL5566821 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL5566821 | — | Ki | = | 72.44 | nM | 7.14 |