Assay Detail
Toxicity
CHEMBL5547883
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hERG by whole cell Qpatch assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of YFJ-36: Design, Synthesis, and Antibacterial Activities of Catechol-Conjugated β-Lactams against Gram-Negative Bacteria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.38 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3989974 | CEFIDEROCOL | 4.0 | 1 | 7.38 |
| CHEMBL5570949 | — | — | 1 | - |
| CHEMBL5575378 | — | — | 1 | - |
| CHEMBL5568939 | — | — | 1 | - |
| CHEMBL5574219 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3989974 | CEFIDEROCOL | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL5570949 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5575378 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5568939 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5574219 | — | IC50 | > | 40000.0 | nM | - |