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Compound Detail

CHEMBL5575378

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C[C@@](O/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(CSCCNC(=O)c3ccc(O)c(O)c3Cl)CS[C@H]12)c1nc(N)sc1Cl)(C(=O)O)C(F)(F)F.O=C(O)C(F)(F)F

Basic Information

ChEMBL ID CHEMBL5575378
Phase Preclinical
Structure Type MOL
InChI Key CNIRILQPOFNWRF-BGNMFLSWSA-N
Parent Compound CHEMBL6070359
Active Moiety CHEMBL6070359
0
Targets
0
Activities
0
Assay Types
4
PK Parameters
6
Publications
0
Known Names

Molecular Properties

803.6
MW (Da)
2.47
ALogP
14
HBA
7
HBD
254.1
PSA (Ų)
0.05
QED
3
Ro5 Violations
13
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C28H24Cl2F6N6O12S3
MW 917.62
Aromatic Rings 2
Heavy Atoms 50
NP-Likeness -0.38

Pharmacokinetic Data

Parameter Value Units Species
AUC 968.0 ng.hr.mL-1 Mus musculus
CL 397.0 mL.min-1.kg-1 Mus musculus
MRT 0.3 hr Mus musculus
T1/2 0.3 hr Mus musculus

Literature References

PubMed DOI Target Context # Activities
38596897 10.1021/acs.jmedchem.4c00265 Acinetobacter baumannii 11
38596897 10.1021/acs.jmedchem.4c00265 Escherichia coli 8
38596897 10.1021/acs.jmedchem.4c00265 Klebsiella pneumoniae 6
38596897 10.1021/acs.jmedchem.4c00265 ADMET 6
38596897 10.1021/acs.jmedchem.4c00265 Pseudomonas aeruginosa 5
38596897 10.1021/acs.jmedchem.4c00265 Voltage-gated inwardly rectifying potassium channel KCNH2 2

Data from ChEMBL 36 via Core Engine