Assay Detail
Binding
CHEMBL5548031
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length nanoluc-fused FGFR4 transfected in HEK293T cells assessed as target engagement incubated for 3 hrs in presence of K10 tracer by Nano BRET assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of Highly Potent and Selective Covalent FGFR4 Inhibitors Based on S<sub>N</sub>Ar Electrophiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.01 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4068896 | — | — | 1 | 7.57 |
| CHEMBL5570033 | — | — | 1 | 7.52 |
| CHEMBL5571683 | — | — | 1 | 7.28 |
| CHEMBL5575075 | — | — | 1 | 5.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4068896 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5570033 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5571683 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL5575075 | — | EC50 | = | 2256.0 | nM | 5.65 |