Assay Detail
Functional
CHEMBL5548032
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Antiproliferative activity against human Hep3B cells measured after 4 days by Celltiter-glo based luminescent assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Hep 3B2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of Highly Potent and Selective Covalent FGFR4 Inhibitors Based on S<sub>N</sub>Ar Electrophiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.29 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5570033 | — | — | 1 | 8.30 |
| CHEMBL5571683 | — | — | 1 | 7.66 |
| CHEMBL4068896 | — | — | 1 | 7.21 |
| CHEMBL5575075 | — | — | 1 | 5.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5570033 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5571683 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4068896 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL5575075 | — | EC50 | = | 1072.0 | nM | 5.97 |