Assay Detail
Functional
CHEMBL5548154
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild type HIV-1 IIIB infected in human MT4 cells assessed as protection against virus-induced cytopathic effect incubated for 5 days by MTT assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of Novel Aryl Triazolone Dihydropyridines (ATDPs) Targeting Highly Conserved Residue W229 as Promising HIV-1 NNRTIs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 26 | 7.09 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2364608 | DORAVIRINE | 4.0 | 1 | 8.10 |
| CHEMBL5571067 | — | — | 1 | 8.10 |
| CHEMBL5575003 | — | — | 1 | 8.05 |
| CHEMBL5573653 | — | — | 1 | 8.00 |
| CHEMBL5575200 | — | — | 1 | 8.00 |
| CHEMBL5573421 | — | — | 1 | 7.96 |
| CHEMBL5593560 | — | — | 1 | 7.96 |
| CHEMBL5564750 | — | — | 1 | 7.92 |
| CHEMBL5563055 | — | — | 1 | 7.82 |
| CHEMBL5570048 | — | — | 1 | 7.51 |
| CHEMBL5566560 | — | — | 1 | 7.39 |
| CHEMBL5574603 | — | — | 1 | 7.33 |
| CHEMBL5570668 | — | — | 1 | 7.21 |
| CHEMBL5566913 | — | — | 1 | 6.80 |
| CHEMBL5567488 | — | — | 1 | 6.78 |
| CHEMBL5568917 | — | — | 1 | 6.72 |
| CHEMBL5567323 | — | — | 1 | 6.71 |
| CHEMBL5570182 | — | — | 1 | 6.68 |
| CHEMBL5573006 | — | — | 1 | 6.58 |
| CHEMBL5569319 | — | — | 1 | 6.55 |
| CHEMBL5572185 | — | — | 1 | 6.44 |
| CHEMBL5565349 | — | — | 1 | 6.43 |
| CHEMBL5563096 | — | — | 1 | 6.36 |
| CHEMBL5592358 | — | — | 1 | 6.02 |
| CHEMBL5593243 | — | — | 1 | 5.69 |
| CHEMBL5574402 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2364608 | DORAVIRINE | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5571067 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5575003 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5573653 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5575200 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5573421 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5593560 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5564750 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5563055 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5570048 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL5566560 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL5574603 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL5570668 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL5566913 | — | EC50 | = | 158.0 | nM | 6.80 |
| CHEMBL5567488 | — | EC50 | = | 168.0 | nM | 6.78 |
| CHEMBL5568917 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5567323 | — | EC50 | = | 195.0 | nM | 6.71 |
| CHEMBL5570182 | — | EC50 | = | 209.0 | nM | 6.68 |
| CHEMBL5573006 | — | EC50 | = | 261.0 | nM | 6.58 |
| CHEMBL5569319 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5572185 | — | EC50 | = | 361.0 | nM | 6.44 |
| CHEMBL5565349 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5563096 | — | EC50 | = | 436.0 | nM | 6.36 |
| CHEMBL5592358 | — | EC50 | = | 959.0 | nM | 6.02 |
| CHEMBL5593243 | — | EC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL5574402 | — | EC50 | = | 5310.0 | nM | 5.28 |