Assay Detail
Functional
CHEMBL5548162
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against NNRTI-resistant HIV-1 harboring F227L/V106A double mutant infected in human MT4 cells assessed as protection against virus-induced cytopathic effect by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of Novel Aryl Triazolone Dihydropyridines (ATDPs) Targeting Highly Conserved Residue W229 as Promising HIV-1 NNRTIs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 4.56 | 4.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5564750 | — | — | 1 | 4.78 |
| CHEMBL5575003 | — | — | 1 | 4.75 |
| CHEMBL5593560 | — | — | 1 | 4.64 |
| CHEMBL5573421 | — | — | 1 | 4.60 |
| CHEMBL5573653 | — | — | 1 | 4.59 |
| CHEMBL5575200 | — | — | 1 | 4.57 |
| CHEMBL5571067 | — | — | 1 | 4.54 |
| CHEMBL5563055 | — | — | 1 | 4.38 |
| CHEMBL2364608 | DORAVIRINE | 4.0 | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5564750 | — | EC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL5575003 | — | EC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL5593560 | — | EC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL5573421 | — | EC50 | = | 24900.0 | nM | 4.60 |
| CHEMBL5573653 | — | EC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL5575200 | — | EC50 | = | 26900.0 | nM | 4.57 |
| CHEMBL5571067 | — | EC50 | = | 29200.0 | nM | 4.54 |
| CHEMBL5563055 | — | EC50 | = | 41800.0 | nM | 4.38 |
| CHEMBL2364608 | DORAVIRINE | EC50 | = | 67800.0 | nM | 4.17 |