Assay Detail
Functional
CHEMBL5548163
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against NNRTI-resistant HIV-1 harboring RES056 mutant infected in human MT4 cells assessed as protection against virus-induced cytopathic effect by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of Novel Aryl Triazolone Dihydropyridines (ATDPs) Targeting Highly Conserved Residue W229 as Promising HIV-1 NNRTIs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.69 | 7.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5575003 | — | — | 1 | 7.23 |
| CHEMBL5573653 | — | — | 1 | 7.04 |
| CHEMBL2364608 | DORAVIRINE | 4.0 | 1 | 6.89 |
| CHEMBL5573421 | — | — | 1 | 6.75 |
| CHEMBL5564750 | — | — | 1 | 6.73 |
| CHEMBL5575200 | — | — | 1 | 6.65 |
| CHEMBL5571067 | — | — | 1 | 6.46 |
| CHEMBL5593560 | — | — | 1 | 6.40 |
| CHEMBL5563055 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5575003 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL5573653 | — | EC50 | = | 91.0 | nM | 7.04 |
| CHEMBL2364608 | DORAVIRINE | EC50 | = | 128.0 | nM | 6.89 |
| CHEMBL5573421 | — | EC50 | = | 177.0 | nM | 6.75 |
| CHEMBL5564750 | — | EC50 | = | 185.0 | nM | 6.73 |
| CHEMBL5575200 | — | EC50 | = | 225.0 | nM | 6.65 |
| CHEMBL5571067 | — | EC50 | = | 344.0 | nM | 6.46 |
| CHEMBL5593560 | — | EC50 | = | 401.0 | nM | 6.40 |
| CHEMBL5563055 | — | EC50 | = | 962.0 | nM | 6.02 |