Assay Detail
Binding
CHEMBL5548199
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human cGAS assessed as dissociation constant measured upto 240 secs by surface plasmon resonance assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Pharmacological Evaluation of Spiro[carbazole-3,3'-pyrrolidine] Derivatives as cGAS Inhibitors for Treatment of Acute Lung Injury.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 7.06 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5082056 | — | — | 1 | 7.28 |
| CHEMBL5573599 | — | — | 1 | 6.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5082056 | — | Kd | = | 53.0 | nM | 7.28 |
| CHEMBL5573599 | — | Kd | = | 146.0 | nM | 6.84 |