Assay Detail
Binding
CHEMBL5548529
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Inhibition of Cathepsin L (unknown origin) assessed as inhibition constant using Z-RR-AMC as fluorogenic substrate by fluorescence based microplate analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.70 | 10.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL286722 | — | — | 1 | 10.31 |
| CHEMBL304784 | — | — | 1 | 10.19 |
| CHEMBL132586 | — | — | 1 | 9.19 |
| CHEMBL406405 | — | — | 1 | 8.82 |
| CHEMBL259450 | — | — | 1 | 7.15 |
| CHEMBL5567183 | — | — | 1 | 6.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL286722 | — | Ki | = | 0.049 | nM | 10.31 |
| CHEMBL304784 | — | Ki | = | 0.0645 | nM | 10.19 |
| CHEMBL132586 | — | Ki | = | 0.64 | nM | 9.19 |
| CHEMBL406405 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL259450 | — | Ki | = | 71.4 | nM | 7.15 |
| CHEMBL5567183 | — | Ki | = | 293.2 | nM | 6.53 |