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Assay Detail

CHEMBL5548923

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of mTOR (unknown origin) by Lance ultra assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Serine/threonine-protein kinase mTOR (CHEMBL2842)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design, Synthesis, Formulation, and Bioevaluation of Trisubstituted Triazines as Highly Selective mTOR Inhibitors for the Treatment of Human Breast Cancer.
Sun Q, Chu Y, Zhang N, Chen R, Wang L, Wu J, Dong Y, Li H, Wang L, Tang L, Zhan C, Zhang JQ.
J Med Chem (2024) 67 : 7330 -7358
PubMed 38661655 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 31 8.04 8.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5564044 1 8.92
CHEMBL5568986 1 8.77
CHEMBL592445 GEDATOLISIB 3.0 1 8.68
CHEMBL5573450 1 8.68
CHEMBL5590872 1 8.66
CHEMBL5566586 1 8.60
CHEMBL5594441 1 8.51
CHEMBL5568982 1 8.48
CHEMBL5568655 1 8.47
CHEMBL5575534 1 8.40
CHEMBL5570798 1 8.38
CHEMBL5575213 1 8.34
CHEMBL5570177 1 8.34
CHEMBL5567159 1 8.32
CHEMBL5573179 1 8.30
CHEMBL5572519 1 8.21
CHEMBL5570389 1 8.14
CHEMBL5575407 1 8.07
CHEMBL5573982 1 7.95
CHEMBL5590918 1 7.70
CHEMBL5564938 1 7.54
CHEMBL5567165 1 7.51
CHEMBL5569846 1 7.50
CHEMBL5566351 1 7.46
CHEMBL5574430 1 7.32
CHEMBL5572006 1 7.28
CHEMBL5573360 1 6.94
CHEMBL5575205 1 6.83
CHEMBL5569305 1 6.78
CHEMBL5575995 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5564044 IC50 = 1.2 nM 8.92
CHEMBL5568986 IC50 = 1.7 nM 8.77
CHEMBL592445 GEDATOLISIB IC50 = 2.1 nM 8.68
CHEMBL5573450 IC50 = 2.1 nM 8.68
CHEMBL5590872 IC50 = 2.2 nM 8.66
CHEMBL5566586 IC50 = 2.5 nM 8.60
CHEMBL5594441 IC50 = 3.1 nM 8.51
CHEMBL5568982 IC50 = 3.3 nM 8.48
CHEMBL5568655 IC50 = 3.4 nM 8.47
CHEMBL5575534 IC50 = 4.0 nM 8.40
CHEMBL5570798 IC50 = 4.2 nM 8.38
CHEMBL5575213 IC50 = 4.6 nM 8.34
CHEMBL5570177 IC50 = 4.6 nM 8.34
CHEMBL5567159 IC50 = 4.8 nM 8.32
CHEMBL5573179 IC50 = 5.0 nM 8.30
CHEMBL5572519 IC50 = 6.2 nM 8.21
CHEMBL5570389 IC50 = 7.2 nM 8.14
CHEMBL5575407 IC50 = 8.5 nM 8.07
CHEMBL5573982 IC50 = 11.2 nM 7.95
CHEMBL5590918 IC50 = 20.0 nM 7.70
CHEMBL5564938 IC50 = 28.5 nM 7.54
CHEMBL5567165 IC50 = 30.6 nM 7.51
CHEMBL5569846 IC50 = 32.0 nM 7.50
CHEMBL5566351 IC50 = 34.6 nM 7.46
CHEMBL5574430 IC50 = 48.3 nM 7.32
CHEMBL5572006 IC50 = 52.5 nM 7.28
CHEMBL5573360 IC50 = 116.0 nM 6.94
CHEMBL5575205 IC50 = 147.2 nM 6.83
CHEMBL5569305 IC50 = 165.1 nM 6.78
CHEMBL5575995 IC50 - -
CHEMBL5576014 IC50 - -