Assay Detail
Binding
CHEMBL5548926
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kgamma (unknown origin) by ADP-glo plus luminescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, Synthesis, Formulation, and Bioevaluation of Trisubstituted Triazines as Highly Selective mTOR Inhibitors for the Treatment of Human Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.70 | 7.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5573179 | — | — | 1 | 7.59 |
| CHEMBL592445 | GEDATOLISIB | 3.0 | 1 | 7.38 |
| CHEMBL5568982 | — | — | 1 | 6.79 |
| CHEMBL5594441 | — | — | 1 | 6.64 |
| CHEMBL5568655 | — | — | 1 | 6.64 |
| CHEMBL5573450 | — | — | 1 | 6.14 |
| CHEMBL5568986 | — | — | 1 | 5.71 |
| CHEMBL5564044 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5573179 | — | IC50 | = | 25.5 | nM | 7.59 |
| CHEMBL592445 | GEDATOLISIB | IC50 | = | 41.4 | nM | 7.38 |
| CHEMBL5568982 | — | IC50 | = | 162.3 | nM | 6.79 |
| CHEMBL5594441 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL5568655 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL5573450 | — | IC50 | = | 725.0 | nM | 6.14 |
| CHEMBL5568986 | — | IC50 | = | 1943.0 | nM | 5.71 |
| CHEMBL5564044 | — | IC50 | > | 10000.0 | nM | - |