Assay Detail
Functional
CHEMBL5548930
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Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, Formulation, and Bioevaluation of Trisubstituted Triazines as Highly Selective mTOR Inhibitors for the Treatment of Human Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.36 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5568986 | — | — | 1 | 6.89 |
| CHEMBL5564044 | — | — | 1 | 5.46 |
| CHEMBL592445 | GEDATOLISIB | 3.0 | 1 | 5.44 |
| CHEMBL5575534 | — | — | 1 | 5.25 |
| CHEMBL5566586 | — | — | 1 | 5.17 |
| CHEMBL5573450 | — | — | 1 | 5.09 |
| CHEMBL5576014 | — | — | 1 | 4.91 |
| CHEMBL5575407 | — | — | 1 | 4.66 |
| CHEMBL5573982 | — | — | 1 | - |
| CHEMBL5568982 | — | — | 1 | - |
| CHEMBL5573179 | — | — | 1 | - |
| CHEMBL5572519 | — | — | 1 | - |
| CHEMBL5594441 | — | — | 1 | - |
| CHEMBL5590918 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5568986 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5564044 | — | IC50 | = | 3460.0 | nM | 5.46 |
| CHEMBL592445 | GEDATOLISIB | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL5575534 | — | IC50 | = | 5672.0 | nM | 5.25 |
| CHEMBL5566586 | — | IC50 | = | 6750.0 | nM | 5.17 |
| CHEMBL5573450 | — | IC50 | = | 8170.0 | nM | 5.09 |
| CHEMBL5576014 | — | IC50 | = | 12440.0 | nM | 4.91 |
| CHEMBL5575407 | — | IC50 | = | 22037.0 | nM | 4.66 |
| CHEMBL5573982 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5568982 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5573179 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5572519 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5594441 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5590918 | — | IC50 | > | 100000.0 | nM | - |