Assay Detail
Binding
CHEMBL5550289
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Xc- in human HT-1080 cells assessed as decrease in glutamate release incubated for 2 hrs by Amplex red assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Ferroptosis and its modulators: A raising target for cancer and Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.26 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5571379 | — | — | 1 | 8.00 |
| CHEMBL5564194 | — | — | 1 | 7.52 |
| CHEMBL5590411 | — | — | 1 | 7.00 |
| CHEMBL5569941 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5571379 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5564194 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5590411 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5569941 | — | IC50 | = | 300.0 | nM | 6.52 |