Assay Detail
Binding
CHEMBL5550425
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant rat DYRK1A kinase domain (1 to 499 residues) expressed in bacteria using KKISGRLSPIMTEQ as substrate incubated for 30 mins in presence of ATP by ADP-Glo kinase assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (CHEMBL5508) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological evaluation of 1H-pyrrolo[3,2-g]isoquinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.31 | 6.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5569099 | — | — | 1 | 6.74 |
| CHEMBL5594716 | — | — | 1 | 6.60 |
| CHEMBL5562930 | — | — | 1 | 6.54 |
| CHEMBL5571626 | — | — | 1 | 6.30 |
| CHEMBL5570490 | — | — | 1 | 6.29 |
| CHEMBL5563473 | — | — | 1 | 6.25 |
| CHEMBL5574139 | — | — | 1 | 6.25 |
| CHEMBL5564481 | — | — | 1 | 6.07 |
| CHEMBL5181620 | — | — | 1 | 6.04 |
| CHEMBL5592689 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5569099 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL5594716 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5562930 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5571626 | — | IC50 | = | 495.0 | nM | 6.30 |
| CHEMBL5570490 | — | IC50 | = | 513.0 | nM | 6.29 |
| CHEMBL5563473 | — | IC50 | = | 564.0 | nM | 6.25 |
| CHEMBL5574139 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL5564481 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL5181620 | — | IC50 | = | 917.0 | nM | 6.04 |
| CHEMBL5592689 | — | IC50 | = | 916.0 | nM | 6.04 |