Assay Detail
Binding
CHEMBL5550428
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CDK9/cyclin T expressed in baculovirus-infected Sf9 cells using YSPTSPSYSPTSPSYSPTSPSKKKK as substrate incubated for 30 mins in presence of ATP by ADP-Glo kinase assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 1H-pyrrolo[3,2-g]isoquinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.56 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5571626 | — | — | 1 | 6.82 |
| CHEMBL5569099 | — | — | 1 | 6.75 |
| CHEMBL5562930 | — | — | 1 | 6.65 |
| CHEMBL5592689 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5571626 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL5569099 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL5562930 | — | IC50 | = | 222.0 | nM | 6.65 |
| CHEMBL5592689 | — | IC50 | = | 999.0 | nM | 6.00 |