Assay Detail
Functional
CHEMBL5550830
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Antiviral activity against HCoV-229E infected in human MRC5 cells assessed as reduction in cytopathic effect pretreated with cells followed by viral infection and measured after 3 days by fluorescence based analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human coronavirus 229E |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploiting high-energy hydration sites for the discovery of potent peptide aldehyde inhibitors of the SARS-CoV-2 main protease with cellular antiviral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.88 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5570210 | — | — | 1 | 7.22 |
| CHEMBL5565685 | — | — | 1 | 7.16 |
| CHEMBL4802135 | NIRMATRELVIR | 4.0 | 1 | 7.00 |
| CHEMBL5565858 | — | — | 1 | 6.96 |
| CHEMBL5595277 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5570210 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5565685 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4802135 | NIRMATRELVIR | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5565858 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5595277 | — | EC50 | = | 900.0 | nM | 6.05 |