Assay Detail
Binding
CHEMBL5551563
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Binding affinity to human PNP assessed as inhibition constant by TR-FRET assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Perspectives and challenges in developing small molecules targeting purine nucleoside phosphorylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 9.47 | 10.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269864 | ULODESINE | 2.0 | 1 | 10.80 |
| CHEMBL473922 | — | — | 1 | 10.38 |
| CHEMBL218291 | FORODESINE | 4.0 | 1 | 10.25 |
| CHEMBL1161035 | — | — | 1 | 8.89 |
| CHEMBL5572384 | — | — | 1 | 8.74 |
| CHEMBL236708 | — | — | 1 | 7.75 |
| CHEMBL475750 | — | — | 1 | - |
| CHEMBL475537 | — | — | 1 | - |
| CHEMBL516050 | — | — | 1 | - |
| CHEMBL505564 | — | — | 1 | - |
| CHEMBL474122 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269864 | ULODESINE | Ki | = | 0.016 | nM | 10.80 |
| CHEMBL473922 | — | Ki | = | 0.042 | nM | 10.38 |
| CHEMBL218291 | FORODESINE | Ki | = | 0.056 | nM | 10.25 |
| CHEMBL1161035 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL5572384 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL236708 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL475750 | — | Ki | = | 0.007 | nM | - |
| CHEMBL475537 | — | Ki | = | 0.0086 | nM | - |
| CHEMBL516050 | — | Ki | = | 0.0034 | nM | - |
| CHEMBL505564 | — | Ki | = | 0.0052 | nM | - |
| CHEMBL474122 | — | Ki | = | 0.0021 | nM | - |