Assay Detail
Binding
CHEMBL5551967
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Covalent inhibition of SARS-CoV-2 main protease
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Discovery of meisoindigo derivatives as noncovalent and orally available M<sup>pro</sup> inhibitors: their therapeutic implications in the treatment of COVID-19.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.85 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5173274 | — | — | 1 | 8.09 |
| CHEMBL4796938 | — | — | 1 | 7.75 |
| CHEMBL4802135 | NIRMATRELVIR | 4.0 | 1 | 7.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5173274 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL4796938 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4802135 | NIRMATRELVIR | IC50 | = | 19.2 | nM | 7.72 |