Assay Detail
Binding
CHEMBL5551968
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Non-covalent inhibition of SARS-CoV-2 main protease
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Discovery of meisoindigo derivatives as noncovalent and orally available M<sup>pro</sup> inhibitors: their therapeutic implications in the treatment of COVID-19.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.06 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5206501 | — | — | 1 | 6.51 |
| CHEMBL1908391 | MASITINIB | 3.0 | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5206501 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1908391 | MASITINIB | IC50 | = | 2500.0 | nM | 5.60 |