Assay Detail

CHEMBL5553503

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Functional

Anti-viral activity against EV-71 (H) infected in human RD cells by MTS assay

ChEMBL ↗

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Target

Enterovirus A71 (CHEMBL612436) ↗

Open DB target context

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Enterovirus A71 (CHEMBL612436) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Enterovirus A71

CHEMBL612436

Anchored from Assay target.

Protein identity Enterovirus A71

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Enterovirus A71
Cell Type	RD
Confidence	1 — Organism
Curated By	Autocuration

Target

Enterovirus A71 (CHEMBL612436) ↗

Type	ORGANISM
Organism	Enterovirus A71

Publication

Discovery of GS-7682, a Novel 4'-Cyano-Modified <i>C</i>-Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys.

Siegel DS, Hui HC, Pitts J, Vermillion MS, Ishida K, Rautiola D, Keeney M, Irshad H, Zhang L, Chun K, Chin G, Goyal B, Doerffler E, Yang H, Clarke MO, Palmiotti C, Vijjapurapu A, Riola NC, Stray K, Murakami E, Ma B, Wang T, Zhao X, Xu Y, Lee G, Marchand B, Seung M, Nayak A, Tomkinson A, Kadrichu N, Ellis S, Barauskas O, Feng JY, Perry JK, Perron M, Bilello JP, Kuehl PJ, Subramanian R, Cihlar T, Mackman RL.
J Med Chem (2024) 67 : 12945 -12968
PubMed 39018526 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	7.39	7.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL283403	ENVIROXIME	2.0	1	7.70
CHEMBL5562532	—	—	1	7.08

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL283403	ENVIROXIME	EC50	=	20.0	nM	7.70
CHEMBL5562532	—	EC50	=	83.0	nM	7.08