Assay Detail
Binding
CHEMBL5553573
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant VEGFR2 (805 to 1356 residues) in presence of ATP by ELISA analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of new 1,3-diphenylurea appended aryl pyridine derivatives as apoptosis inducers through c-MET and VEGFR-2 inhibition: design, synthesis, <i>in vivo</i> and <i>in silico</i> studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.70 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1289601 | LENVATINIB | 4.0 | 1 | 8.40 |
| CHEMBL1946170 | REGORAFENIB | 4.0 | 1 | 8.38 |
| CHEMBL5594061 | — | — | 1 | 7.62 |
| CHEMBL2105717 | CABOZANTINIB | 4.0 | 1 | 7.60 |
| CHEMBL3764045 | TAS-115 | 1.0 | 1 | 7.52 |
| CHEMBL5593609 | — | — | 1 | 7.46 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 7.05 |
| CHEMBL5571331 | — | — | 1 | 6.54 |
| CHEMBL5574745 | — | — | 1 | 6.51 |
| CHEMBL5568824 | — | — | 1 | 6.50 |
| CHEMBL5595346 | — | — | 1 | 6.12 |
| CHEMBL5575208 | — | — | 1 | 6.07 |
| CHEMBL5565651 | — | — | 1 | 6.07 |
| CHEMBL5583996 | — | — | 1 | 6.04 |
| CHEMBL5574737 | — | — | 1 | 5.96 |
| CHEMBL5565430 | — | — | 1 | 5.93 |
| CHEMBL5572702 | — | — | 1 | 5.85 |
| CHEMBL5579755 | — | — | 1 | 5.80 |
| CHEMBL5574727 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1289601 | LENVATINIB | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1946170 | REGORAFENIB | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL5594061 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2105717 | CABOZANTINIB | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3764045 | TAS-115 | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5593609 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5571331 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5574745 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL5568824 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL5595346 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5575208 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL5565651 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL5583996 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL5574737 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5565430 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL5572702 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL5579755 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL5574727 | — | IC50 | = | 1580.0 | nM | 5.80 |