Compound Detail
CHEMBL5579755
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Basic Information
| ChEMBL ID | CHEMBL5579755 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DAKXNUPYTGXHIM-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
456.5
MW (Da)
6.79
ALogP
4
HBA
3
HBD
98.0
PSA (Ų)
0.28
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.09
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatocyte growth factor receptor CHEMBL3717 | IC50 | 6.09 | 6.09 | 810.0 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 5.8 | 5.8 | 1580.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hepatocyte growth factor receptor | IC50 | = | 810.0 | nM | 6.09 | Inhibition of N-terminal GST-tagged human recombinant c-MET (956 to 1390 residue... | 39026631 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 1580.0 | nM | 5.8 | Inhibition of human recombinant VEGFR2 (805 to 1356 residues) in presence of ATP... | 39026631 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 39026631 | 10.1039/d4md00280f | Hepatocyte growth factor receptor | 1 |
| 39026631 | 10.1039/d4md00280f | Vascular endothelial growth factor receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine