Assay Detail
Binding
CHEMBL5553707
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human thrombin using Boc-QAR-AMC as substrate assessed as inhibition constant by fluorescence based analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rational <i>In Silico</i> Design of Selective TMPRSS6 Peptidomimetic Inhibitors via Exploitation of the S2 Subpocket.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.87 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4081543 | — | — | 1 | 7.28 |
| CHEMBL5569457 | — | — | 1 | 6.92 |
| CHEMBL5562937 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4081543 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL5569457 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL5562937 | — | Ki | = | 395.0 | nM | 6.40 |