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Assay Detail

CHEMBL5553830

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human MIA PaCa-2 cells incubated for 48 to 72 hrs by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MIA PaCa-2
Confidence 1 — Organism
Curated By Autocuration

Target

MIA PaCa-2 (CHEMBL614725)
Type CELL-LINE
Organism Homo sapiens

Publication

A Comprehensive <i>In Vitro</i> Characterization of a New Class of Indole-Based Compounds Developed as Selective Haspin Inhibitors.
Vestuto V, Ciaglia T, Musella S, Di Sarno V, Smaldone G, Di Matteo F, Scala MC, Napolitano V, Miranda MR, Amodio G, Novi S, Pepe G, Basilicata MG, Gazzillo E, Pace S, Gomez-Monterrey IM, Sala M, Bifulco G, Tecce MF, Campiglia P, Ostacolo C, Lauro G, Manfra M, Bertamino A.
J Med Chem (2024) 67 : 12711 -12734
PubMed 39038808 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 24 5.63 6.32

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5178368 1 6.32
CHEMBL5564324 1 6.19
CHEMBL5566041 1 5.88
CHEMBL5568999 1 5.67
CHEMBL5595605 1 5.59
CHEMBL5574302 1 5.38
CHEMBL5563118 1 5.25
CHEMBL5575835 1 4.78
CHEMBL5591651 1 -
CHEMBL5570156 1 -
CHEMBL5576026 1 -
CHEMBL5565688 1 -
CHEMBL5564624 1 -
CHEMBL5595763 1 -
CHEMBL5591618 1 -
CHEMBL5563528 1 -
CHEMBL5574750 1 -
CHEMBL5571554 1 -
CHEMBL5583809 1 -
CHEMBL5566424 1 -
CHEMBL5593072 1 -
CHEMBL5575484 1 -
CHEMBL5572441 1 -
CHEMBL428647 PACLITAXEL 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5178368 EC50 = 480.0 nM 6.32
CHEMBL5564324 EC50 = 650.0 nM 6.19
CHEMBL5566041 EC50 = 1330.0 nM 5.88
CHEMBL5568999 EC50 = 2120.0 nM 5.67
CHEMBL5595605 EC50 = 2560.0 nM 5.59
CHEMBL5574302 EC50 = 4220.0 nM 5.38
CHEMBL5563118 EC50 = 5680.0 nM 5.25
CHEMBL5575835 EC50 = 16430.0 nM 4.78
CHEMBL5591651 EC50 > 20000.0 nM -
CHEMBL5570156 EC50 > 20000.0 nM -
CHEMBL5576026 EC50 > 20000.0 nM -
CHEMBL5565688 EC50 > 20000.0 nM -
CHEMBL5564624 EC50 > 20000.0 nM -
CHEMBL5595763 EC50 > 20000.0 nM -
CHEMBL5591618 EC50 > 20000.0 nM -
CHEMBL5563528 EC50 > 20000.0 nM -
CHEMBL5574750 EC50 > 20000.0 nM -
CHEMBL5571554 EC50 > 20000.0 nM -
CHEMBL5583809 EC50 > 20000.0 nM -
CHEMBL5566424 EC50 > 20000.0 nM -
CHEMBL5593072 EC50 > 20000.0 nM -
CHEMBL5575484 EC50 > 20000.0 nM -
CHEMBL5572441 EC50 > 20000.0 nM -
CHEMBL428647 PACLITAXEL EC50 = 0.002 nM -