Compound Detail
CHEMBL5595763
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Basic Information
| ChEMBL ID | CHEMBL5595763 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CWGGMWVMXOQDJW-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
442.6
MW (Da)
4.27
ALogP
5
HBA
3
HBD
83.5
PSA (Ų)
0.38
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.95
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase haspin CHEMBL1075163 | IC50 | 5.95 | 5.95 | 1135.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase haspin | IC50 | = | 1135.0 | nM | 5.95 | Inhibition of human haspin preincubated for 30 mins followed by ATP and ULight-h... | 39038808 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 39038808 | 10.1021/acs.jmedchem.4c00718 | Serine/threonine-protein kinase haspin | 1 |
| 39038808 | 10.1021/acs.jmedchem.4c00718 | Raji | 1 |
| 39038808 | 10.1021/acs.jmedchem.4c00718 | HeLa | 1 |
| 39038808 | 10.1021/acs.jmedchem.4c00718 | A-375 | 1 |
| 39038808 | 10.1021/acs.jmedchem.4c00718 | MIA PaCa-2 | 1 |
| 39038808 | 10.1021/acs.jmedchem.4c00718 | MCF7 | 1 |
| 39038808 | 10.1021/acs.jmedchem.4c00718 | IEC-6 | 1 |
Data from ChEMBL 36 via Core Engine