Assay Detail
Functional
CHEMBL5554473
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Modulation of human UTR stably expressed in HEK293 cells assessed as increase in Ca2+ level by Fura 2-AM dye based calcium mobilization assay
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Expanding Structure-Activity Relationships of Human Urotensin II Peptide Analogues: A Proposed Key Role of the N-Terminal Region for Novel Urotensin II Receptor Modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 2 | - | - |
| EC50 | 2 | 9.07 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL593662 | UROTENSIN-II | — | 2 | 9.22 |
| CHEMBL218994 | — | — | 2 | 8.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL593662 | UROTENSIN-II | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL218994 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL218994 | — | Activity | - | — | - | |
| CHEMBL593662 | UROTENSIN-II | Activity | - | — | - |